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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Depression in frontotemporal dementia.

David M Blass¹, Peter V Rabins

¹Abarbanel Mental Health Center, 15 Keren Kayemet St., Bat Yam, Israel. dmblass@jhmi.edu

|July 2, 2009

Summary

This summary is machine-generated.

Mood abnormalities are common in frontotemporal dementia (FTD). Three distinct depressive syndromes, including major depression, mood lability, and apathy, were identified in FTD patients.

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Area of Science:

Neuroscience
Psychiatry
Gerontology

Background:

Frontotemporal dementia (FTD) is a neurodegenerative disorder.
Mood disturbances are increasingly recognized in FTD.

Observation:

A case series of frontotemporal dementia (FTD) patients were reviewed.
Mood abnormalities were systematically analyzed.

Findings:

Three distinct depressive syndromes were identified in FTD patients.
These syndromes include major depression, mood lability with environmental responsiveness, and profound apathy.
Apathy without other depressive features was noted as a distinct syndrome.

Implications:

The findings highlight the diverse mood disorders associated with FTD.
Accurate differential diagnosis is crucial when evaluating mood abnormalities in older adults.
Frontotemporal dementia (FTD) should be considered in the differential diagnosis of unexplained mood changes.