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Related Experiment Video

Updated: Jun 22, 2026

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

Published on: March 6, 2026

Botox therapy for ischemic digits.

Michael W Neumeister¹, Christopher B Chambers, Margo S Herron

¹Springfield, Ill. From the Plastic Surgery Institute, Southern Illinois University School of Medicine.

Plastic and Reconstructive Surgery

|July 2, 2009

Summary

This summary is machine-generated.

Botulinum toxin type A (Botox) injections effectively reduced chronic pain and healed ulcers in most Raynaud

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Published on: June 2, 2015

Area of Science:

Vascular Medicine
Pain Management
Regenerative Medicine

Background:

Raynaud's phenomenon presents significant challenges in managing chronic pain and ulcerations.
Current treatments like vasodilators and sympathectomies offer variable benefits.
Botulinum toxin type A (Botox) is explored as a novel therapeutic option.

Purpose of the Study:

To evaluate the outcomes of botulinum toxin type A (Botox) injections in patients with Raynaud's phenomenon experiencing chronic pain and ulcerations.
To assess the impact of Botox on pain reduction and tissue perfusion.

Main Methods:

A retrospective study analyzed outcomes in 19 patients with Raynaud's phenomenon and chronic ischemic hand pain.
Botox (50-100 units) was injected into the palm around neurovascular bundles.
Laser Doppler scanning measured blood flow changes pre- and post-injection.

Main Results:

84% of patients reported reduced pain at rest, with 13 experiencing immediate relief.
All patients with chronic finger ulcers healed within 60 days.
Significant improvements in digital blood flow were observed, with long-term pain relief in 63% after a single injection.

Conclusions:

Botox injections demonstrated significant improvement in vascular perfusion and pain reduction in Raynaud's patients refractory to conservative treatments.
The findings suggest Botox as a promising treatment for Raynaud's phenomenon, warranting further research.
Abnormal vascular function in Raynaud's phenomenon may be positively modulated by Botox, though the precise mechanism requires elucidation.