Related Experiment Video

Updated: Jun 22, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based

Rosebud O Roberts1, Yonas E Geda, David S Knopman

  • 1Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. roberts.rosebud@-mayo.edu

Alzheimer Disease and Associated Disorders
|July 2, 2009
PubMed

Insights

Metabolic syndrome (MetS) combined with inflammation is linked to nonamnestic mild cognitive impairment (na-MCI) in older adults. This suggests inflammation plays a key role in specific types of cognitive decline.

Area of Science:

  • Neurology
  • Gerontology
  • Internal Medicine

Background:

  • Metabolic syndrome (MetS) is increasingly recognized for its association with cognitive impairment.
  • The interplay between MetS, inflammation, and different subtypes of mild cognitive impairment (MCI) requires further investigation.
  • Understanding these relationships is crucial for identifying specific risk factors and potential interventions for cognitive decline in aging populations.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MetS), with and without inflammation, and mild cognitive impairment (MCI).
  • To differentiate the impact of MetS and inflammation on amnestic MCI (a-MCI) versus nonamnestic MCI (na-MCI).
  • To explore potential etiologic differences between MCI subtypes based on metabolic and inflammatory profiles.

Main Methods:

  • A randomly selected cohort of 1969 participants aged 70-89 years was studied.
  • Participants underwent neurologic evaluation, neuropsychologic testing, and biochemical assays for inflammation markers like C-reactive protein (CRP).
  • Diagnoses included normal cognition, MCI (a-MCI and na-MCI), and dementia; MetS components were clinically ascertained and biochemically confirmed.

Main Results:

  • Metabolic syndrome (MetS) alone was not significantly associated with either nonamnestic MCI (na-MCI) or amnestic MCI (a-MCI).
  • High C-reactive protein (CRP) levels were associated with na-MCI but not a-MCI.
  • The combination of MetS and high CRP was significantly associated with na-MCI, but not with a-MCI.

Conclusions:

  • The combined presence of metabolic syndrome and high inflammation is specifically associated with nonamnestic mild cognitive impairment in the elderly.
  • These findings suggest distinct underlying etiologies for different subtypes of mild cognitive impairment.
  • Inflammation appears to be a critical factor mediating the relationship between MetS and specific forms of cognitive impairment.

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...