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Updated: Jun 22, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

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Published on: August 5, 2014

Stability Of Default-Mode Network Activity In The Aging Brain.

L L Beason-Held1, M A Kraut, S M Resnick

  • 1Laboratory of Personality and Cognition, National Institute on Aging, NIH.

Brain Imaging and Behavior
|July 2, 2009
PubMed
Summary
This summary is machine-generated.

The default-mode network remains stable in healthy older adults over eight years. This stability in brain activity may help differentiate normal aging from pathological conditions.

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Last Updated: Jun 22, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

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Published on: December 28, 2010

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Aging

Background:

  • The default-mode network (DMN) is active during rest and linked to intrinsic cognitive processes.
  • While DMN activity changes across the lifespan, its stability in healthy aging is not well understood.
  • Understanding DMN stability is crucial for distinguishing normal aging from neurodegenerative diseases.

Purpose of the Study:

  • To investigate the longitudinal stability of DMN activity in healthy older adults.
  • To examine changes in rest-specific brain activity over an 8-year period.
  • To identify brain regions demonstrating stable versus changing activity patterns in aging.

Main Methods:

  • Utilized positron emission tomography (PET) to measure regional cerebral blood flow (rCBF).
  • Compared resting-state and recognition memory task conditions at baseline and 8-year follow-up.
  • Analyzed data from older participants in the Baltimore Longitudinal Study of Aging (BLSA) neuroimaging study.

Main Results:

  • Key DMN regions (medial frontal/anterior cingulate, hippocampus, posterior cingulate) showed stable rest-specific activity over 8 years.
  • Non-DMN regions (prefrontal, parahippocampal, occipital cortex) exhibited changes in activity over time.
  • The core components of the default-mode network demonstrated remarkable stability in healthy older individuals.

Conclusions:

  • The default-mode network's core regions are relatively stable in healthy aging.
  • This stability offers a potential biomarker for normal aging.
  • Findings may aid in identifying factors distinguishing normal from pathological brain aging.