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A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease
Je Hyun Seo1, Hyeong Gon Yu, Hum Chung
1Department of Ophthalmology, College of Medicine, and Medical Research Center, Seoul National University, Seoul, Korea.
Abstract:
A case of Vogt-Koyanagi-Harada disease (VKH) that developed in a 36-year-old woman with Graves' disease was described. The patient was treated with Lugol's solution and presented with bilateral serous retinal detachment. She had also suffered from methimazole-induced hypersensitivity and steroid-induced myopathy. Fluorescein angiography showed multiple leakage points and a lumbar puncture revealed pleocytosis, which was compatible with VKH. High dose steroid pulse therapy was successful. Altered immune regulation associated with drug-induced hypersensitivity may contribute to the development of VKH in patients with Graves' disease.
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