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Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Exercise reduces effects of creatine on lung.
R P Vieira1, A C Duarte, A B G Santos
1Albert-Ludwigs University of Freiburg, Germany. rodrelena@yahoo.com.br
International Journal of Sports Medicine
|July 2, 2009
Summary
Aerobic exercise mitigated the negative effects of creatine supplementation on allergic asthma in mice. This suggests exercise may counteract creatine
Area of Science:
- Immunology
- Respiratory Medicine
- Exercise Physiology
Background:
- Creatine supplementation has been shown to exacerbate features of allergic lung sensitization.
- Aerobic exercise is known to inhibit allergic airway inflammation and remodeling.
- The combined effects of creatine and exercise on asthma models require investigation.
Purpose of the Study:
- To investigate if aerobic exercise can reduce the exacerbatory effects of creatine supplementation in a murine model of asthma.
- To evaluate the impact of low-intensity exercise combined with creatine on allergic airway inflammation and remodeling.
Main Methods:
- Balb/c mice were divided into six groups, including control, creatine, and ovalbumin-sensitized groups with or without creatine and low-intensity exercise.
- Sensitization and aerosol challenges were performed using ovalbumin (OVA).
- Creatine treatment and low-intensity exercise were administered over several weeks.
Main Results:
- In ovalbumin-sensitized mice receiving creatine, co-administration of low-intensity exercise significantly decreased eosinophils in bronchoalveolar lavage fluid and airways.
- Exercise also reduced inflammatory cells positive for IL-4 and IL-5, as well as airway collagen and elastic fiber content.
- Significant reductions were observed in airway smooth muscle thickness and bronchoconstriction index in the exercise + creatine group compared to the creatine-only group.
Conclusions:
- Aerobic exercise effectively counteracts the exacerbatory effects of creatine supplementation on allergic airway inflammation and remodeling in a mouse model of asthma.
- These findings suggest a potential therapeutic role for aerobic exercise in managing asthma in individuals using creatine supplements.
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