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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Biodegradable nitric oxide-releasing poly(diol citrate) elastomers.

Haichao Zhao1, M Concepcion Serrano, Daniel A Popowich

  • 1Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA.

Journal of Biomedical Materials Research. Part A
|July 2, 2009
PubMed
Summary

Researchers created new nitric oxide (NO)-releasing poly(diol citrate) elastomers. These materials offer sustained NO delivery for two days and show promise for medical devices needing blood contact or cell proliferation control.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Engineering

Background:

  • Nitric oxide (NO) plays crucial roles in vascular function and wound healing.
  • Developing materials for localized and sustained NO release is critical for advanced medical applications.
  • Existing NO-releasing materials often face challenges with stability, release kinetics, and biocompatibility.

Purpose of the Study:

  • To synthesize and characterize novel poly(diol citrate) elastomers capable of sustained nitric oxide (NO) release.
  • To evaluate the mechanical properties, degradability, and cell compatibility of these novel elastomers.
  • To assess the feasibility of incorporating these NO-releasing elastomers into expanded polytetrafluoroethylene (ePTFE) vascular grafts.

Main Methods:

  • Poly(diol citrate) prepolymers synthesized via condensation of citric acid, 1,8-octanediol, and N,N'-bis(2-hydroxyethyl)ethylenediamine.
  • Elastomeric films prepared by solvent casting and crosslinking; vascular grafts fabricated by coating ePTFE with prepolymer.
  • Materials subjected to diazeniumdiolation for NO release, followed by mechanical testing, cell proliferation assays (porcine aortic smooth muscle cells - PASMC), and degradation studies in PBS.

Main Results:

  • Poly(diol citrate) elastomers exhibited tunable mechanical properties (Young's modulus: 5.91–32.64 MPa, ultimate tensile stress: 1.47–10.71 MPa, elongation at break: 200–260%).
  • The elastomers demonstrated degradability and excellent compatibility with PASMC, with degradation rates independent of secondary amine content.
  • Sustained NO release for two days was achieved from both modified films and ePTFE vascular grafts.

Conclusions:

  • Novel diazeniumdiolated poly(diol citrate) elastomers offer tunable mechanical properties, biocompatibility, and sustained NO release.
  • These materials show potential for use in medical devices, particularly those requiring blood contact or modulation of cell proliferation.
  • The successful integration into ePTFE grafts highlights their applicability in vascular tissue engineering and regenerative medicine.