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Measuring gene mutation in vivo
J A Heddle1, M A Khan, C Urlando
1Department of Biology, York University, Toronto, Ontario, Canada.
Progress in Clinical and Biological Research
|January 1, 1991
Abstract:
Both chromosomal aberrations and intragenic mutations are important in the activation of oncogenes and inactivation of antioncogenes. It is now possible to measure both types of mutational events in vivo in a single cell type. The results obtained in both Chinese hamsters and rats are surprising: mutations can be induced in the absence of detectable chromosomal aberrations by some agents and vice versa by others. Preliminary results from a validation study are presented.