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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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Related Experiment Video

Updated: Jun 22, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Longitudinal diffusion-weighted imaging in infants with hydrocephalus: decrease in tissue water diffusion after

Paul H Leliefeld1, Rob H J M Gooskens, Kees P J Braun

  • 1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands. p.h.leliefeld@umcutrecth.nl

Journal of Neurosurgery. Pediatrics
|July 3, 2009
PubMed
Summary
This summary is machine-generated.

Diffusion-weighted imaging quantified cerebral edema in infants with hydrocephalus. Cerebrospinal fluid (CSF) diversion rapidly decreased this edema, indicating its reversibility and aiding in risk assessment for brain damage.

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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Last Updated: Jun 22, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
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Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Medical Physics

Background:

  • Progressive hydrocephalus can cause periventricular white matter edema and brain damage due to compression, stretching, and ischemia.
  • Quantifying cerebral edema in infants with hydrocephalus is crucial for understanding disease progression and treatment efficacy.

Purpose of the Study:

  • To investigate the utility of diffusion-weighted imaging (DWI) in quantifying cerebral edema in infants with hydrocephalus.
  • To determine if cerebrospinal fluid (CSF) diversion can effectively decrease cerebral edema.

Main Methods:

  • Diffusion-weighted MR imaging was performed on 24 infants before and after CSF diversion.
  • Apparent diffusion coefficients (ADCs) were calculated for various brain regions and compared to age-related normal values.
  • Intracranial pressure (ICP) and mean arterial blood pressure were monitored.

Main Results:

  • Post-CSF diversion, mean ADC values significantly decreased, particularly in the periventricular white matter, confirming preoperative edema.
  • Preoperative ADC values were elevated compared to normal, decreasing postoperatively but remaining within the normal range.
  • A significant linear correlation was found between ADC values and ICP, with ICP decreasing post-diversion.

Conclusions:

  • DWI can quantify reversible interstitial or vasogenic edema in infants with hydrocephalus.
  • The observed rapid decrease in ADC post-CSF diversion exceeds physiological age-related changes.
  • These findings may help differentiate progressive from compensated hydrocephalus and identify infants at risk of cerebral damage.