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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Related Experiment Video

Updated: Jun 22, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Polyhydroxyalkanoates: materials for delivery systems.

G A Nobes1, R H Marchessault, D Maysinger

  • 1Department of Chemistry, McGill University, Montreal, Canada.

Drug Delivery
|July 3, 2009
PubMed
Summary
This summary is machine-generated.

Polyhydroxyalkanoates are promising biodegradable polymers for novel drug delivery systems. This review highlights their properties and potential applications, despite limited research.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Current medical polymers have limitations.
  • Polyhydroxyalkanoates (PHAs) offer biodegradable and biocompatible alternatives.
  • PHAs are naturally derived polyesters with tunable properties.

Purpose of the Study:

  • To provide an overview of polyhydroxyalkanoates (PHAs) for drug delivery.
  • To compare PHAs with existing medical polymers.
  • To review PHA-based drug delivery systems and their potential.

Main Methods:

  • Literature review of polyhydroxyalkanoates.
  • Analysis of biochemical and physical properties.
  • Review of existing PHA-based drug delivery systems.

Main Results:

  • Polyhydroxyalkanoates exhibit favorable biocompatibility and biodegradability.
  • PHA properties can be tailored through biosynthesis and processing.
  • Examples of PHA use in delivering anticancer, antiviral, and contraceptive drugs were identified.

Conclusions:

  • Polyhydroxyalkanoates show significant potential for advanced drug delivery applications.
  • Further research is needed to fully explore PHA capabilities and overcome limitations.
  • PHAs represent a viable alternative to conventional drug delivery materials.