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Related Concept Videos

COP Coated Vesicles00:59

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jun 22, 2026

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
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Published on: January 19, 2020

Polymer-coated vesicles: development and characterization.

N Venkatesan1, S P Vyas

  • 1Department of Pharmaceutical Sciences, Doctor Harisingh Gour Vishwavidyalaya, Sagar, India.

Drug Delivery
|July 3, 2009
PubMed
Summary
This summary is machine-generated.

Polymer-coated niosomes demonstrate enhanced stability and controlled release kinetics. These polyacrylonitrile-coated vesicles maintain integrity under osmotic stress, offering potential for improved drug delivery systems.

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Last Updated: Jun 22, 2026

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Niosomes are non-ionic surfactant vesicles used in drug delivery.
  • Improving niosome stability and controlling drug release are key challenges.
  • Polymer coating offers a potential strategy to enhance niosome performance.

Purpose of the Study:

  • To prepare and characterize polyacrylonitrile-coated niosomes.
  • To compare the physical characteristics and release profiles of coated versus plain niosomes.
  • To evaluate the effect of osmotic stress on coated niosome stability and release.

Main Methods:

  • Interfacial pH induced polymerization technique for polyacrylonitrile coating.
  • Characterization of niosome shape, size, and lamellarity.
  • In vitro drug release studies under varying osmotic conditions.

Main Results:

  • Polymer-coated niosomes maintained shape and size under osmotic stress.
  • Slightly higher trapping efficiency and slower, anomalous release kinetics (near zero-order) observed for coated niosomes.
  • No significant change in release rate profile under osmotic variations for coated vesicles.

Conclusions:

  • Polyacrylonitrile coating enhances niosome stability against osmotic stress.
  • Coated niosomes exhibit controlled, near zero-order release kinetics.
  • These findings suggest potential for improved drug delivery applications using polymer-coated niosomes.