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Vancomycin release from blended polyester microspheres.

T W Atkins¹, D J Yates

¹Department of Pharmaceutical and Biological Sciences, Aston University, Aston Triangle, Birmingham, UK. T.W.Atkins@aston.ac.uk

|July 3, 2009

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This study fabricated vancomycin-loaded microspheres using O/W emulsification. Different polymer blends influenced drug release, with some formulations showing sustained release up to 20 days in serum.

Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Vancomycin is a critical antibiotic for treating serious bacterial infections.
Developing effective drug delivery systems is essential for optimizing antibiotic therapy.
Biodegradable polymers offer potential for controlled release of therapeutic agents.

Purpose of the Study:

To fabricate and characterize vancomycin-loaded microspheres using O/W emulsification and solvent evaporation.
To investigate the effect of different polymer compositions (PLCG 50:50, PEAD, P(HB-HV)) on microsphere properties and vancomycin encapsulation.
To evaluate the in vitro release kinetics of vancomycin from the fabricated microspheres in different media.

Main Methods:

Fabrication of spherical microspheres (5-100 microm) via O/W emulsification and solvent evaporation.

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Utilized various polymer blends: PLCG 50:50, PEAD, 50% PEAD/50% PLCG 50:50, and 75% P(HB-HV)/25% PLCG 50:50.

Analyzed microsphere surface morphology, diameter, vancomycin encapsulation efficiency, and in vitro release profiles.

Main Results:

Microsphere surface morphology varied from smooth and macroporous to rugose and microporous based on polymer composition.
High vancomycin encapsulation efficiencies (>64%) were observed for PLCG 50:50, PEAD, and 50% PEAD/50% PLCG 50:50.
Release profiles exhibited an initial burst followed by sustained release up to 20 days, influenced by polymer blend and incubation medium (serum vs. buffer).

Conclusions:

Polymer composition significantly impacts vancomycin-loaded microsphere characteristics and drug release kinetics.
Formulations containing PLCG 50:50 and PEAD demonstrated high encapsulation and sustained release, particularly in newborn calf serum.
These vancomycin-loaded microspheres show potential as effective drug delivery systems for treating infections.