Related Experiment Video

Updated: Jun 22, 2026

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction

Birgit A Steppich1, Siegmund Lorenz Braun, Andreas Stein

  • 1Medizinische Klinik, Klinikum rechts der Isar der Technischen Universität München, , Munich, Germany. steppich@dhm.mhn.de

Thrombosis Journal
|July 3, 2009
PubMed

Insights

High plasma tissue factor (TF) activity in patients with acute myocardial infarction (AMI) is linked to a poorer prognosis and increased cardiovascular mortality. This finding highlights TF as a potential marker for predicting atherothrombotic risk in ACS patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Tissue factor (TF) plays a critical role in thrombosis following plaque disruption in acute coronary syndromes (ACS).
  • Understanding the prognostic implications of plasma TF activity is crucial for managing ACS patients.

Purpose of the Study:

  • To investigate the impact of plasma TF activity on prognosis in patients with ACS.
  • To determine if plasma TF activity can serve as a predictive marker for atherothrombotic risk.

Main Methods:

  • Plasma TF activity was measured in 174 unstable Angina pectoris (uAP) and 112 acute myocardial infarction (AMI) patients.
  • Patients were categorized into high (TF >24 pmol/L) and low (TF ≤ 24 pmol/L) TF activity groups.
  • Survival analysis using Kaplan-Meier and Cox proportional hazards models was performed over a mean follow-up of 3.26 years.

Main Results:

  • In AMI patients, higher TF activity was significantly associated with cardiovascular death (40.9 ± 7.96 pmol/L in non-survivors vs. 24.9 ± 2.78 pmol/L in survivors, P = 0.024).
  • Kaplan-Meier analysis showed significantly lower survival rates in AMI patients with high TF activity (81.3% vs. 92.2%, P = 0.03).
  • Cox regression identified plasma TF activity as an independent predictor of survival in AMI (hazard ratio 9.27, P = 0.03). Circulating microparticles were identified as the primary source of plasma TF activity.

Conclusions:

  • Systemic TF activity in AMI possesses unfavorable prognostic value.
  • Plasma TF activity can serve as a marker for dysregulated coagulation.
  • TF activity may enhance the prediction of atherothrombotic risk in ACS patients.
Abstract

More Related Videos

Extracellular Vesicle Tissue Factor Activity Assay03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...