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Related Experiment Videos

Tussock moth dermatitis: evidence for histamine involvement.

H S Lee1, G H Tan, Y M Khoo

  • 1Department of Pharmacology, Faculty of Medicine, National University of Singapore.

Reviews on Environmental Health
|January 1, 1991
PubMed
Summary

Histamine, a key inflammatory mediator, was identified in tussock moth hairs. This finding provides evidence that moth hairs contribute to pruritic dermatitis outbreaks.

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Area of Science:

  • Toxicology
  • Dermatology
  • Entomology

Background:

  • An outbreak of pruritic dermatitis in Singapore was linked to tussock moth hairs.
  • The specific causative agents within the moth hairs were not previously identified.

Purpose of the Study:

  • To investigate the presence of histamine in tussock moth hairs.
  • To determine if histamine in moth hairs contributes to pruritic dermatitis.

Main Methods:

  • Aqueous extraction of moth hairs.
  • Pharmacological testing on isolated guinea pig ileum.
  • High-performance liquid chromatography (HPLC) and mass spectrometry (MS) analysis of derivatives.

Main Results:

  • Moth hair extract mimicked histamine's effects on guinea pig ileum, blocked by mepyramine.

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  • HPLC analysis showed identical retention times for moth extract and histamine derivatives.
  • Mass spectrometry confirmed identical derivative structures for moth extract and histamine.

    • Conclusions:

    • Histamine is present in tussock moth hairs.
    • Histamine is implicated as an inflammatory mediator in tussock moth-induced pruritic dermatitis.