Related Experiment Video
Updated: Jun 22, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Clear cell carcinoma: review of its histomorphogenesis and classification as a squamous cell lesion
1Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario.
Abstract:
In current classification schemes, clear cell carcinoma-including both the hyalinized and nonhyalinized variety--is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the typical histomorphology of this neoplasm remains unclear. This review summarizes and illustrates the histologic, ultrastructural, and immunohistochemical evidence for the underlying squamous cell nature of clear cell carcinoma. Squamous cell differentiation is not an uncommon feature of nonneoplastic and neoplastic lesions of the salivary glands. Clear cell carcinoma needs to be added to this list as a unique but specific variety of clear cell squamous carcinoma.
Related Concept Videos
Classification of Epithelial Tissues: Overview
Based on the number of cell layers,...
Classification of Epithelial Tissues: Stratified Epithelium
Cellular Adaptation IV: Dysplasia and Metaplasia
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Classification of Epithelial Tissues: Glandular Epithelium
Multicellular glands are formed during early development when epithelial budding...
Classification of Epithelial Tissues: Simple Epithelium
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
