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Dysplastic kidneys in children - do they grow?
Nia Fraser1, Anu Paul, A R Williams
1Department of Paediatric Urology, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Level E, East Block, Nottingham, UK. nia.fraser@ntlworld.com
Journal of Pediatric Urology
|July 3, 2009
Summary
Dysplastic kidneys (DK) show poor growth and changes in appearance, which predict chronic kidney disease (CKD) development. Serial ultrasounds are recommended for monitoring these pediatric kidney conditions.
Area of Science:
- Pediatric Nephrology
- Radiology
- Medical Imaging
Background:
- Dysplastic kidneys (DK) are a frequent cause of chronic kidney disease (CKD) in children.
- Limited understanding exists regarding the growth patterns and evolving sonographic features of DK.
Purpose of the Study:
- To investigate the growth velocity of DK in children.
- To identify sonographic indicators that predict the development of CKD in pediatric patients with DK.
Main Methods:
- Retrospective analysis of ultrasound scans from children diagnosed with DK.
- Evaluation of renal length against standard growth charts and assessment of dysplastic features.
- Correlation of imaging findings with clinical data, including associated uropathies and renal function.
Main Results:
- Over half of the DK kidneys exhibited suboptimal growth velocity, falling off their expected length centiles.
- A significant correlation was observed between reduced renal length growth and the onset of CKD.
- Progressive decline in corticomedullary differentiation was noted in 53% of DK, also correlating with CKD development.
Conclusions:
- Poor renal growth and specific sonographic abnormalities in DK are highly predictive of CKD.
- Regular serial ultrasonography is crucial for monitoring renal growth and identifying progressive changes in children with DK.
- These findings underscore the importance of imaging in managing pediatric kidney disease.
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