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Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

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Lower urinary tract dysfunction in acute disseminated encephalomyelitis.

J N Panicker¹, D Nagaraja, J M E Kovoor

¹Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. j.panicker@ion.ucl.ac.uk

Multiple Sclerosis (Houndmills, Basingstoke, England)

|July 3, 2009

Summary

Lower urinary tract dysfunction (LUTD) is common in acute disseminated encephalomyelitis (ADEM), affecting one-third of patients. While associated with neurological deficits, LUTD does not predict overall functional outcome, though symptoms may persist.

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Last Updated: Jun 22, 2026

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

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Published on: November 4, 2017

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

Neurology
Urology

Background:

Lower urinary tract dysfunction (LUTD) is well-documented in multiple sclerosis.
Its prevalence and outcomes in acute disseminated encephalomyelitis (ADEM) are less understood.

Purpose of the Study:

To investigate the occurrence and characteristics of LUTD in ADEM patients.
To correlate LUTD with other neurological deficits and functional outcomes.

Main Methods:

Evaluation of ADEM patients with significant LUTD using symptom analysis, ultrasonography, and urodynamics.
Management included antimuscarinics for storage symptoms and catheterization for voiding dysfunction.

Main Results:

20 out of 61 (33%) ADEM patients presented with LUTD.
Voiding dysfunction, particularly urinary retention, was common. Detrusor overactivity/underactivity observed in urodynamics.
LUTD correlated with frontoparietal white matter changes and lower limb pyramidal involvement but not functional outcome.

Conclusions:

LUTD is a frequent complication of ADEM, often linked to neurological deficits.
While not impacting overall functional recovery, LUTD may persist, indicating incomplete resolution.