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Molecular mechanisms to improve nerve regeneration following damage to the immature peripheral nervous system

Peter Bannerman1, Michelle A James

  • 1Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA. pgbannerman@ucdavis.edu

The Journal of Bone and Joint Surgery. American Volume
|July 3, 2009
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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