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Updated: Jun 22, 2026
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Published on: March 19, 2014
The role of human orbitofrontal cortex in value comparison for incommensurable objects.
Thomas H B FitzGerald1, Ben Seymour, Raymond J Dolan
1Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom. thomas.fitzgerald@iop.kcl.ac.uk
Summary
The human orbitofrontal cortex evaluates choices between different goods, reflecting the value difference between options for both gains and losses. This brain region is crucial for decision-making involving complex, incomparable items.
Area of Science:
- Neuroscience
- Cognitive Science
- Decision Science
Background:
- The orbitofrontal cortex (OFC) is known for its role in appetitive valuation.
- It remains unclear if the OFC supports comparative valuation for complex choices.
Purpose of the Study:
- To investigate the role of the OFC in comparative valuation for incommensurable goods.
- To determine if OFC activation reflects value differences or choice probabilities.
Main Methods:
- A binary choice paradigm was used to derive subjective values of goods bundles.
- fMRI was employed to measure brain activation during gain and loss conditions.
Main Results:
- OFC activation correlated with the subjective value difference between choice options.
- This OFC valuation effect was observed for both gains and losses.
- Dorsal striatum and supplementary motor areas showed activation related to choice probabilities.
Conclusions:
- The human orbitofrontal cortex is critical for comparative valuation of incommensurable goods.
- OFC's role in reflecting value differences is a key component of human decision-making.
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