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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Related Experiment Video

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long noncoding RNAs: functional surprises from the RNA world.

Jeremy E Wilusz1, Hongjae Sunwoo, David L Spector

  • 1Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Genes & Development
|July 3, 2009
PubMed
Summary

Long noncoding RNAs (lncRNAs) are abundant transcripts with crucial cellular roles. Recent studies reveal diverse functions for lncRNAs, including gene regulation and protein interaction, highlighting their importance in cell biology and disease.

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Last Updated: Jun 22, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Published on: April 10, 2018

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Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • Eukaryotic genomes produce a vast array of transcripts, including numerous long noncoding RNAs (lncRNAs).
  • Many lncRNAs, despite lacking protein-coding potential, show cell-type-specific expression and are linked to human diseases.
  • The functional significance of most lncRNAs remains largely uncharacterized.

Purpose of the Study:

  • To review recent findings on the molecular functions of long noncoding RNAs.
  • To emphasize the diverse regulatory roles lncRNAs play in cellular processes.
  • To underscore the growing understanding of lncRNAs as key regulatory molecules.

Main Methods:

  • Literature review of recent research on lncRNA functions.
  • Analysis of studies demonstrating lncRNA involvement in gene expression regulation.
  • Compilation of evidence for lncRNAs' roles in protein localization, activity, and RNA processing.

Main Results:

  • lncRNA transcription can directly influence the expression of neighboring genes.
  • lncRNAs actively regulate protein activity, localization, and cellular structures.
  • lncRNAs can be processed into small RNAs or modulate the processing of other RNAs.
  • lncRNAs exhibit diverse functional mechanisms, acting as key regulators.

Conclusions:

  • Long noncoding RNAs are not transcriptional noise but critical regulatory molecules.
  • lncRNAs perform functions previously attributed solely to proteins.
  • The multifaceted roles of lncRNAs are essential for cellular regulation and biological processes.