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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cytotoxic bisnor- and norditerpene dilactones having 7alpha,8alpha-epoxy-9,11-enolide substructure from Podocarpus
Kimihiko Sato1, Yasunori Inaba, Hyun-Sun Park
1School of Pharmacy, Tokyo University of Pharmacy & Life Science.
Abstract:
Fourteen new bisnor- and norditerpene dilactones, makilactones E-R, having a 7alpha : 8alpha-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnor- and norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.
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