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Updated: Jun 22, 2026

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
Published on: February 25, 2007
Parental stress before, during, and after pediatric stem cell transplantation: a review article
C M J Vrijmoet-Wiersma1, R M Egeler, H M Koopman
1Pediatric Department, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. c.m.j.vrijmoet-wiersma@lumc.nl
Insights
Parental stress during pediatric stem cell transplantation (SCT) peaks before and during the acute phase. Identifying at-risk parents early is crucial for providing necessary support throughout the SCT journey.
Area of Science:
- Pediatric Hematology/Oncology
- Child Psychology
- Family Medicine
Background:
- Pediatric stem cell transplantation (SCT) is a demanding treatment for children with serious health conditions.
- Parents experience significant psychological distress throughout their child's SCT journey.
- Understanding parental adaptation is vital for effective supportive care.
Purpose of the Study:
- To conduct a literature review on parental distress and adaptation during pediatric SCT.
- To identify risk and protective factors influencing parental psychological adjustment.
- To synthesize current knowledge on parental stress before, during, and after SCT.
Main Methods:
- Systematic literature search of PubMed, Web of Science, PsychInfo, and Picarta databases.
- Inclusion criteria: articles published 1990-2009, focusing on parents of pediatric SCT patients, examining psychological outcomes, and in English.
- Analysis of 18 selected articles on parental stress and adaptation.
Main Results:
- Parental stress is highest in the pre-SCT period and during the acute phase of treatment.
- Stress levels generally decrease after hospital discharge for most parents.
- A subset of parents experience persistent elevated stress post-SCT, particularly those with high acute-phase stress.
Conclusions:
- Psychosocial assessments are essential before, during, and after SCT to identify parents needing support.
- Early identification of at-risk parents facilitates timely intervention and follow-up care.
- Targeted support can mitigate long-term parental distress associated with pediatric SCT.
Goals Of Work:
Pediatric stem cell transplantation (SCT) is a stressful treatment for children with relapsed or high-risk malignancies, immune deficiencies and certain blood diseases. Parents of children undergoing SCT can experience ongoing stress related to the SCT period. The aim of this article was to present a literature review of articles on parental distress and adaptation before, during, and after SCT and to identify risk and protective factors.
Materials And Methods:
The review was conducted systematically by using PubMed, Web of Science, PsychInfo, and Picarta databases. Eighteen articles met our inclusion criteria: publishing date between January 1, 1990 and January 1, 2009; studies concerning parents of children undergoing SCT; studies examining the psychological adjustment and/or stress reactions of parents as primary outcomes and studies available in English.
Main Results:
Highest levels of parental stress are reported in the period preceding SCT and during the acute phase. Stress levels decrease steadily after discharge in most parents. However, in a subgroup of parents, stress levels still remain elevated post-SCT. Parents most at risk in the longer term display highest levels of stress during the acute phase of the SCT.
Conclusions:
Psychosocial assessment before SCT, during the acute phase and in the longer term, is necessary to identify parents in need for support and follow-up care.
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