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Updated: Jun 22, 2026
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays
Jie Qiu1, Qin Hong, Rong-hua Chen
1Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004, Nanjing, China. jieqiu@yahoo.cn
Abstract:
We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.
