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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Evaluation of a rapid, multiphase MRE sequence in a heart-simulating phantom.
Arunark Kolipaka1, Kiaran P McGee, Philip A Araoz
1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Magnetic Resonance in Medicine
|July 3, 2009
Summary
Multiphase magnetic resonance elastography (MRE) accurately estimates phantom stiffness compared to single-phase MRE. This multiphase MRE technique shows stability and potential for imaging dynamic organs like the heart.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Rheology
Background:
- Magnetic Resonance Elastography (MRE) is crucial for assessing tissue stiffness.
- Standard MRE techniques may face limitations in imaging rapidly deforming tissues.
- Developing advanced MRE sequences is essential for dynamic organ assessment.
Purpose of the Study:
- To validate stiffness estimates from multiphase MRE against single-phase MRE.
- To assess the stability of multiphase MRE stiffness measurements under varying conditions.
- To explore the feasibility of multiphase MRE for dynamic organ imaging.
Main Methods:
- A spherical rubber phantom underwent cyclic pressure variations (18-72 bpm).
- Single-phase and multiphase MRE sequences were used for imaging.
- A spherical shell wave inversion algorithm calculated shear stiffness.
Main Results:
- A strong linear correlation (R² = 0.98) was found between stiffness and pressure.
- Stiffness estimates from multiphase and single-phase MRE showed good agreement.
- Multiphase MRE stiffness estimates remained stable when image acquisition occupied ≤42% of the deformation period.
Conclusions:
- Multiphase MRE provides reliable stiffness estimations comparable to single-phase MRE.
- The multiphase MRE technique demonstrates robustness and stability for dynamic assessments.
- This method holds significant promise for non-invasive imaging of organs like the heart.
