Related Experiment Video

Updated: Jun 22, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

Nucleophile assisting leaving groups: a strategy for aliphatic 18F-fluorination.

Shuiyu Lu1, Salvatore D Lepore, Song Ye Li

  • 1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1003, USA. shuiyu.lu@mail.nih.gov

The Journal of Organic Chemistry
|July 4, 2009
PubMed
Summary

New arylsulfonate nucleophile assisting leaving groups (NALGs) enhance halogenation and radiofluorination reactions. These novel leaving groups improve yields, offering a stable alternative to traditional methods.

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