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Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
Obedience01:08

Obedience

According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation, obedience...

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Related Experiment Video

Updated: Jun 22, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Suicidality among Finnish anaesthesiologists.

P M Lindfors1, O A Meretoja, R A Luukkonen

  • 1Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, HUS, Helsinki, Finland. pirjo.lindfors@kolumbus.fi

Acta Anaesthesiologica Scandinavica
|July 4, 2009
PubMed
Summary

Physician suicide rates are high, with anesthesiologists showing significant suicidal ideation. Poor health, low social support, and workplace issues like conflicts and on-call stress are key risk factors.

Related Experiment Videos

Last Updated: Jun 22, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Area of Science:

  • Medical Research
  • Occupational Health
  • Psychiatry

Background:

  • Physician suicide rates exceed the general population.
  • Anesthesiologists exhibit particularly high rates of suicide.
  • Understanding risk factors is crucial for prevention.

Purpose of the Study:

  • To investigate the prevalence of suicidal ideation among Finnish anesthesiologists.
  • To identify personal and occupational risk factors associated with suicidality in this group.

Main Methods:

  • Cross-sectional questionnaire study.
  • Survey distributed to 550 working Finnish anesthesiologists.
  • Response rate of 60% achieved.

Main Results:

  • One in four anesthesiologists reported serious suicidal ideation.
  • Significant risk factors included poor health, low social support, family problems, workplace conflicts, and on-call stress.
  • Each additional risk factor doubled the likelihood of suicidality.

Conclusions:

  • Suicidal ideation is a significant concern among Finnish anesthesiologists.
  • Screening for risk factors and recognizing affected physicians is essential for intervention.
  • Addressing interpersonal relationships, decision-making, and on-call burden is key for suicide prevention in physicians.