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Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
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Nephrocalcinosis in children: a retrospective multi-centre study.

Anita Ammenti1, Alessandra Pelizzoni, Milvia Cecconi

  • 1Department of Pediatrics, University of Parma, Parma, Italy. anitason@unipr.it

Acta Paediatrica (Oslo, Norway : 1992)
|July 4, 2009
PubMed
Summary

Treatment of underlying conditions in children with nephrocalcinosis (NC) improves growth and stabilizes kidney function. Early diagnosis is key, though NC degree may not decrease with treatment.

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Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Child Growth and Development

Background:

  • Nephrocalcinosis (NC) in children presents with diverse symptoms including failure to thrive and urinary tract infections.
  • Hereditary tubulopathies and vitamin D intoxication are primary causes of NC.

Purpose of the Study:

  • To analyze the etiology, clinical features, growth, and renal function in children with NC.
  • To correlate growth and renal function with NC progression over time.

Main Methods:

  • Retrospective data collection from 41 children across four institutions.
  • Analysis of clinical presentation, glomerular function, and growth parameters during follow-up.

Main Results:

  • Normal glomerular function at diagnosis in 83% of patients.
  • Median follow-up of 4 years and 5 months showed improved growth (SDS -2.2 to -1.0) and stable renal function in 89%.
  • NC severity worsened in 62% despite treatment.

Conclusions:

  • Treatment of underlying causes promotes catch-up growth and renal function stability in pediatric NC.
  • Early recognition and diagnosis of NC are crucial for effective management.
  • A diagnostic flowchart is proposed to aid in approaching NC.