Hexokinase and 'glucokinase' in liver metabolism
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A Cornish-Bowden1, M L Cárdenas
1Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, Marseille, France.
Trends in Biochemical Sciences
|August 1, 1991
Abstract:
Rat liver contains four hexokinase isoenzymes, one of which, despite often being called 'glucokinase', is no more specific for glucose than the others. However, it does differ from them in displaying a sigmoid kinetic response to glucose, requiring much higher glucose concentrations for activity, and being insensitive to physiological concentrations of glucose 6-phosphate.