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Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition
1Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
Trends in Biochemical Sciences
|August 1, 1991
Abstract:
The highly conserved DNA-binding domain of the steroid hormone receptors contains two 'zinc finger'-like sequence motifs. The three-dimensional structure in solution has been determined using two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy and shows that the two 'zinc finger'-like motifs fold to form a single structural domain. The combination of this structural information and mutagenesis data reveals how this family of transcriptional regulators bind to DNA.