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Published on: May 6, 2018
Post-menopausal hormone use and albuminuria.
Emily L Schopick1, Naomi D Fisher, Julie Lin
1Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. eschopick@partners.org
Summary
Post-menopausal hormone use exceeding six years is linked to reduced urinary albumin excretion in women. This finding suggests a potential protective effect of longer-term hormone therapy on kidney health markers.
Area of Science:
- Nephrology
- Endocrinology
- Women's Health
Background:
- Elevated urinary albumin excretion is a predictor of hypertension and chronic kidney disease.
- Post-menopausal hormone (PMH) use may impact renal function and albuminuria, but the association is unclear.
Purpose of the Study:
- To investigate the relationship between the duration of post-menopausal hormone use and albuminuria in non-diabetic women.
- To determine if longer duration of PMH use is associated with lower levels of urinary albumin excretion.
Main Methods:
- Cross-sectional study of 2445 post-menopausal, non-diabetic women from the Nurses' Health Study.
- Categorization of PMH users by duration of use (< or =3 years to >15 years).
- Multivariate logistic regression analysis to assess the association between PMH use duration and top decile of urine albumin/creatinine ratio (ACR).
Main Results:
- Current PMH use of >6 years was associated with lower odds of being in the top ACR decile (OR=0.55).
- No significant dose-response relationship was observed.
- Shorter duration of current PMH use and past PMH use were not associated with albumin excretion.
Conclusions:
- Current post-menopausal hormone use for over six years is associated with lower urinary albumin excretion in non-diabetic women.
- This suggests a potential renal protective effect of prolonged PMH use in this population.
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