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Updated: Jun 21, 2026
06:17
Measuring the Strength of Mice
Published on: June 2, 2013
In this issue of Blood, ter Brugge and colleagues describe the results of their efforts to express SV40 T antigen in mature B cells of mice. As a consequence of T antigen expression, B cells develop normally but, upon aging, mice show an accumulation of monoclonal CD5(+) B cells and have a chronic lymphocytic leukemia-like phenotype.
In this issue of Blood, ter Brugge and colleagues describe the results of their efforts to express SV40 T antigen in mature B cells of mice. As a consequence of T antigen expression, B cells develop normally but, upon aging, mice show an accumulation of monoclonal CD5(+) B cells and have a chronic lymphocytic leukemia-like phenotype.
