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Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism

A Ekmekci1, N Abaci, N Colak Ozbey

  • 1Department of Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Journal of Endocrinological Investigation
|July 4, 2009
PubMed

Insights

Primary hyperparathyroidism (pHT) impairs endothelial function, which improves after parathyroid surgery. The endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism does not appear to influence this endothelial dysfunction in pHT patients.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Genetics

Background:

  • Symptomatic primary hyperparathyroidism (pHT) is linked to increased cardiovascular risks.
  • Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is implicated in cardiovascular diseases.
  • Endothelial dysfunction is a key factor in cardiovascular morbidity.

Purpose of the Study:

  • To assess endothelial function in pHT patients pre- and post-surgery.
  • To investigate the role of eNOS intron 4a/b polymorphism in pHT-related endothelial dysfunction.

Main Methods:

  • Flow-mediated dilation (FMD) of the brachial artery was used to measure endothelial function.
  • Forty pHT patients and 43 healthy controls were included.
  • eNOS4a/b polymorphism was analyzed using polymerase chain reaction.

Main Results:

  • Pre-operative FMD was significantly lower in pHT patients compared to controls.
  • FMD improved significantly post-parathyroidectomy but remained lower than controls.
  • Increased serum calcium and PTH levels predicted lower FMD; eNOS4a/b polymorphism did not.

Conclusions:

  • Successful parathyroid surgery improves endothelial function in pHT patients.
  • eNOS4a/b polymorphism does not appear to significantly modify endothelial function in this patient group.
Abstract

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