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Related Experiment Video

Updated: Jun 21, 2026

Olfactory Behavioral Testing in the Adult Mouse
09:00

Olfactory Behavioral Testing in the Adult Mouse

Published on: January 28, 2009

Simple behavioral assessment of mouse olfaction.

Mu Yang1, Jacqueline N Crawley

  • 1National Institute of Mental Health, NIH, Bethesda, Maryland, USA.

Current Protocols in Neuroscience
|July 4, 2009
PubMed
Summary

Assess mouse sense of smell with two simple tests for volatile and distinct odors. These methods for evaluating anosmia (loss of smell) are easy to implement in most labs.

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Area of Science:

  • Neuroscience
  • Animal Behavior

Background:

  • Assessing olfactory function is crucial for understanding sensory processing in animal models.
  • Existing methods for evaluating smell in mice can be complex or time-consuming.

Purpose of the Study:

  • To present two basic, rapid protocols for assessing olfactory abilities in mice.
  • To provide straightforward methods for detecting volatile and distinct odors, including social cues.

Main Methods:

  • The buried food test was employed to evaluate the detection of volatile odors.
  • The olfactory habituation/dishabituation test was used to assess odor detection and differentiation.
  • An alternate protocol included non-contact odor presentation and urine sample collection.

Main Results:

  • The described protocols offer rapid assessments of anosmia (absence of smell).
  • The methods are adaptable for evaluating responses to both nonsocial and social odors.
  • Simple equipment requirements facilitate widespread adoption.

Conclusions:

  • Two accessible protocols for evaluating mouse olfaction are presented.
  • These tests provide a foundation for studying olfactory deficits and sensory perception in mice.
  • The methods are suitable for routine use in most research laboratories.

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Last Updated: Jun 21, 2026

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