Related Experiment Video
Updated: Jun 21, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Developing multicomponent interventions using fractional factorial designs
Bibhas Chakraborty1, Linda M Collins, Victor J Strecher
1Department of Statistics and The Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. bibhas@umich.edu
Abstract:
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions.
More Related Videos
10:26Problem-Solving Before Instruction (PS-I): A Protocol for Assessment and Intervention in Students with Different Abilities
Published on: September 11, 2021
13:54A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
Published on: August 18, 2023
Related Concept Videos
Factorial Design
Methods of Medium Optimization
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Experimental Designs
Dosage Regimens: Designs and Approaches
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs