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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Monocytes and Macrophages in Asthma.

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Impact of London's low emission zone on air quality and children's respiratory health: a sequential annual cross-sectional study.

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Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.

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Related Experiment Video

Updated: Jun 21, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Aspirin-sensitive respiratory disease.

Sophie P Farooque1, Tak H Lee

  • 1King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Guy's Hospital, London SE1 9RT, England.

Annual Review of Physiology
|July 7, 2009
PubMed
Summary
This summary is machine-generated.

Aspirin-sensitive respiratory disease (ASRD) involves severe airway inflammation. Desensitization with aspirin offers long-term benefits for patients with this condition.

Related Experiment Videos

Last Updated: Jun 21, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Area of Science:

  • Immunology
  • Pulmonology
  • Pharmacology

Background:

  • Aspirin-sensitive respiratory disease (ASRD) is a severe inflammatory condition affecting the upper and lower airways.
  • Key features include chronic eosinophilic rhinosinusitis, nasal polyposis, and asthma.
  • Aspirin or COX-1 inhibitor ingestion triggers life-threatening airway exacerbations.

Purpose of the Study:

  • To review the molecular, cellular, and biochemical characteristics of ASRD.
  • To identify knowledge gaps and suggest future research directions.

Main Methods:

  • Literature review of studies on ASRD pathogenesis and treatment.
  • Analysis of molecular, cellular, and biochemical abnormalities.

Main Results:

  • ASRD pathogenesis involves eicosanoid pathway dysregulation and significant mast cell/eosinophilic infiltration.
  • Aspirin desensitization is effective for long-term clinical improvement in most patients.
  • Selective COX-2 inhibitors may be tolerated by individuals with aspirin sensitivity.

Conclusions:

  • Understanding ASRD requires further investigation into its complex molecular and cellular underpinnings.
  • Targeted therapies and improved management strategies are needed for ASRD patients.