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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Jun 21, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

[Olfactory neuroblastoma with unusual structures: a clinical pathologic study].

Qian Yao1, Chang-li Yue, Zhi-chun Lü

  • 1Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|July 7, 2009
PubMed
Summary

Olfactory neuroblastoma (ONB) can exhibit unusual pathological features, including epithelial components. Tumor necrosis indicates a poor prognosis, while mucous cells suggest a good prognosis for olfactory neuroblastoma patients.

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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

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Last Updated: Jun 21, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Area of Science:

  • Pathology
  • Oncology
  • Histology

Context:

  • Olfactory neuroblastoma (ONB) is a rare tumor arising from the olfactory epithelium.
  • Understanding its pathological variations is crucial for accurate diagnosis and prognosis.

Purpose:

  • To investigate unusual pathological features of olfactory neuroblastoma (ONB).
  • To correlate these features with clinical prognosis using histology and immunohistochemistry.

Summary:

  • Forty ONB cases were analyzed. Unusual findings included epithelial components (mucous/squamous cells), in-situ invasion, and papillary proliferation.
  • Hyams Grading did not correlate with prognosis. Necrosis was linked to poor outcomes (P=0.016), while mucous cells indicated a good prognosis (P=0.011).

Impact:

  • Identifies prognostic indicators in ONB, namely tumor necrosis (poor) and mucous cells (good).
  • Suggests ONB may arise from bipotential differentiation of olfactory epithelium basal cells.
  • Highlights the diagnostic significance of recognizing unusual pathological structures in ONB.