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Updated: Jun 21, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
Published on: July 3, 2020
[Effects of simvastatin on the immune-related genes of mouse osteoblasts]
Fei Hu1, Xue-yang Zhang, Lei Zhou
1Department of Orthodontics, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.
Objective:
To investigate the expression of immune-related genes during osteogenesis stimulated by simvastatin.
Methods:
After treated with simvastatin, the expression of immune-related genes of mouse osteoblast was examined with gene chip (BiostarM-140s).
Results:
There were 16 differently expressed genes related to immune function, with nine down-regulated genes and seven up-regulated genes.
Conclusions:
After treated with simvastatin, expression of inflammation related genes is down-regulated and inflammation inhibitor genes is up-regulated in mouse osteoblasts.
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