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Updated: Jun 21, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Drug-induced lupus]
Ma Angeles Aguirre Zamorano1, Rosario López Pedrera, Ma Jose Cuadrado Lozano
1Servicio de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain. maaguirrezamorano@yahoo.es
Medicina Clinica
|July 7, 2009
Summary
Drug-induced lupus (DIL) presents with lupus-like symptoms and positive antinuclear antibodies (ANA) after drug exposure. Symptoms usually resolve upon drug withdrawal, with treatment reserved for severe cases.
Area of Science:
- Rheumatology
- Pharmacology
- Immunology
Context:
- Drug-induced lupus (DIL) is a condition mimicking systemic lupus erythematosus (SLE).
- It arises from exposure to specific medications, leading to characteristic clinical and serological changes.
- While many drugs induce antinuclear antibodies (ANA), only a subset causes DIL.
Purpose:
- To define drug-induced lupus (DIL), its clinical manifestations, and serological findings.
- To differentiate DIL from idiopathic SLE, particularly concerning antibody profiles.
- To outline the diagnostic criteria and management strategies for DIL.
Summary:
- DIL involves lupus-like symptoms (fever, arthralgia, myalgia) and positive ANA, predominantly anti-histone antibodies.
- Antibodies to ds-DNA are rare in DIL, except with anti-TNF agents and minocycline, which can present uniquely.
- Diagnosis requires clinical features alongside serological evidence; renal and CNS involvement are infrequent.
Impact:
- Understanding DIL aids in accurate diagnosis and appropriate patient management.
- Identifying causative drugs and their specific antibody profiles improves treatment strategies.
- Prompt drug withdrawal typically leads to symptom resolution, minimizing the need for aggressive therapies.
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