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Published on: April 22, 2019
Primary intraosseous squamous cell carcinomas: five new clinicopathologic case studies
1Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. yamada@md.okayama-u.ac.jp
Summary
Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare jaw tumors. Early diagnosis and surgical removal offer good prognoses for these odontogenic epithelial remnant cancers.
Area of Science:
- Oral and Maxillofacial Surgery
- Oncology
- Pathology
Background:
- Primary intraosseous squamous cell carcinomas (PIOSCCs) originate from odontogenic epithelial remnants.
- PIOSCCs represent a rare but significant group of malignant jaw tumors.
Purpose of the Study:
- To report on five new cases of PIOSCC.
- To analyze the clinical, radiographic, and histopathological features of PIOSCC.
- To discuss treatment outcomes and prognostic factors.
Main Methods:
- Retrospective case series analysis.
- Review of clinical, radiographic, and histopathological data.
- Evaluation of treatment modalities and patient follow-up.
Main Results:
- Five cases (3 female, 2 male; mean age 64.4 years) of PIOSCC were identified.
- Lesions occurred in the maxilla (1) and mandible (4), presenting as ill-defined radiolucencies.
- Histopathology revealed four well-differentiated and one moderately differentiated PIOSCC; most arose de novo.
- Surgical excision with adjuvant therapy was performed in four cases.
- Three patients showed no recurrence or metastasis; one had local recurrence, and one rejected treatment.
Conclusions:
- PIOSCCs are critical considerations among radiolucent jaw lesions.
- Early diagnosis and wide surgical excision are crucial for favorable outcomes.
- Multidisciplinary treatment approaches may improve PIOSCC management.