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[Neolignans from Piper polysyphorum C.DC].

Y Ma1, G Q Han, C L Li

  • 1School of Pharmaceutical Sciences, Beijing Medical University.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Researchers discovered a new neolignan, polysyphorin, from Piper polysyphorum, exhibiting platelet-activating factor (PAF) inhibitory activity. This finding contributes to the search for novel PAF inhibitors from natural sources.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Context:

  • Piper polysyphorum, a plant native to southern China, was investigated for bioactive compounds.
  • Screening for inhibitors of platelet-activating factor (PAF) identified promising activity in the plant's nonpolar fraction.

Purpose:

  • To isolate and characterize novel chemical constituents from Piper polysyphorum.
  • To evaluate the platelet-activating factor (PAF) inhibitory potential of isolated compounds.

Summary:

  • A new neolignan, polysyphorin, along with three new enantiomeric forms (virolongin, grandisin, lancifolin D) and two known neolignans (wallichinine, hancinone D) were isolated from Piper polysyphorum.
  • Polysyphorin was identified as a racemic enantiomer with the structure threo-delta 7'-7-hydroxy-3,4,5,3',5'-pentamethoxy-8-O-4'-neolignan.

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  • Spectroscopic methods (UV, IR, CD, MS, NMR) and derivative preparation were used for structural elucidation.

    • Impact:

    • The isolation of polysyphorin and other neolignans provides new chemical entities for further pharmacological studies.
    • The identified PAF inhibitory activity suggests potential therapeutic applications for Piper polysyphorum derivatives in conditions involving PAF.