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Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
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Negative BOLD effect on somato-motor inhibitory processing: an fMRI study.

Hiroki Nakata1, Kiwako Sakamoto, Antonio Ferretti

  • 1ITAB-Institute for Advanced Biomedical Technologies, Gabriele D'Annunzio University Foundation, Chieti, Italy. nakata@nips.ac.jp

Neuroscience Letters
|July 7, 2009
PubMed
Summary

This study investigated neural mechanisms of inhibitory control using fMRI. Findings show the right superior frontal gyrus (SFG) is deactivated during response inhibition, regardless of task type.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Imaging

Background:

  • Inhibitory control is crucial for regulating behavior and cognition.
  • Neural underpinnings of response inhibition remain debated.
  • Functional magnetic resonance imaging (fMRI) is a key tool for studying brain activity.

Purpose of the Study:

  • To investigate the neural mechanisms of response inhibitory processing.
  • To evaluate the negative blood oxygen level dependent (BOLD) effect during go/no-go tasks.
  • To determine if inhibitory processing deactivation is modality-dependent.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • Fifteen subjects performed two somatosensory go/no-go tasks: button press and counting.
  • Go and no-go stimuli were presented with equal probability.

Main Results:

  • A common negative BOLD effect was observed in the right superior frontal gyrus (SFG), corresponding to Brodmann area 8 (BA 8).
  • This deactivation occurred during both Movement No-go and Count No-go trials.
  • The observed neural response was independent of the specific response mode required.

Conclusions:

  • The right SFG (BA 8) plays a significant role in response inhibitory processing.
  • This region exhibits a negative BOLD effect during inhibition, suggesting a deactivation mechanism.
  • The inhibitory function of the right SFG appears to be independent of the motor or cognitive response modality.