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Uric acid levels and outcome from coronary artery bypass grafting

Graham S Hillis1, Brian H Cuthbertson, Patrick H Gibson

  • 1Department of Cardiology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, United Kingdom. ghillis@george.org.au

The Journal of Thoracic and Cardiovascular Surgery
|July 7, 2009
PubMed

Insights

Elevated serum uric acid levels predict poorer survival after coronary artery bypass grafting (CABG). Higher uric acid is linked to increased mortality risk, independent of other cardiac surgery risk factors.

Area of Science:

  • Cardiology
  • Biochemistry
  • Surgical Outcomes

Background:

  • Elevated uric acid is linked to adverse cardiovascular outcomes.
  • The prognostic value of uric acid in coronary artery bypass grafting (CABG) patients is unknown.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and outcomes in patients undergoing CABG.
  • To determine if uric acid is an independent predictor of mortality after CABG.

Main Methods:

  • Prospective cohort study of 1140 patients undergoing non-emergency CABG.
  • Serum uric acid measured preoperatively.
  • Primary endpoint: all-cause mortality assessed over a median of 4.5 years.

Main Results:

  • 126 deaths (11%) occurred during follow-up.
  • Higher mean uric acid levels in non-survivors (390 ± 131 µmol/L) vs. survivors (353 ± 86 µmol/L).
  • Elevated uric acid (≥410 µmol/L) significantly predicted mortality, even after adjusting for European System for Cardiac Operative Risk Evaluation (EuroSCORE).

Conclusions:

  • Increasing serum uric acid levels are associated with reduced survival post-CABG.
  • Uric acid serves as an independent prognostic marker for mortality after coronary artery bypass grafting.
  • This finding adds to the understanding of cardiovascular risk stratification in surgical patients.
Abstract

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