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Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo
L Roux1, A E Simon, J J Holland
1Département de Microbiologie, CMU, Geneva, Switzerland.
Advances in Virus Research
|January 1, 1991
Abstract:
DI viruses and defective viruses generally are widespread in nature. Laboratory studies show that they can sometimes exert powerful disease-modulating effects (either attenuation or intensification of symptoms). Their role in nature remains largely unexplored, despite recent suggestive evidence for their importance in a number of systems.