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Updated: Jun 21, 2026
11:16
In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
Published on: February 10, 2023
[Hyaluronidase: Here we go again]
B Etesse1, L Beaudroit, M Deleuze
1Pôle Anesthésie-Douleur-urgences-Réanimation, Groupe Hospitalo-Universitaire Carémeau, 30029 Nîmes cedex 09, France.
Annales Francaises D'Anesthesie Et De Reanimation
|July 7, 2009
Summary
Hyaluronidase (H) improves ophthalmic anesthesia by enhancing block quality and reducing intraocular pressure. Despite its benefits, H is unavailable in France, but recombinant H may offer a future solution.
Area of Science:
- Ophthalmology
- Anesthesiology
- Pharmacology
Context:
- Hyaluronidase (H) has been utilized as an adjuvant in ophthalmic anesthesia for over 50 years.
- Its use aims to improve anesthetic efficacy and mitigate potential complications.
- Current unavailability of H in France presents a clinical challenge.
Purpose:
- To review the advantages and adverse effects of hyaluronidase in ophthalmic anesthesia.
- To discuss the current lack of availability of hyaluronidase in French clinical practice.
- To explore the potential of recombinant hyaluronidase as a future alternative.
Summary:
- Hyaluronidase acts as a "spreading factor," enhancing regional anesthesia quality and onset speed in ophthalmic surgery.
- It helps limit acute intraocular pressure spikes post-injection and may protect against local anesthetic-induced myotoxicity, reducing strabismus.
- Despite a long history of use, studies on H have yielded varied results, and it is currently unavailable in France.
Impact:
- Hyaluronidase appears to be a valuable adjunct for improving ophthalmic anesthesia outcomes.
- The unavailability of H in France necessitates exploration of alternatives.
- Recombinant hyaluronidase presents a promising future solution for ophthalmic anesthesia practices.
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