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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jun 21, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

[Pediatric liver transplantation].

Dominique Debray1, Olivier Bernard, Frédéric Gauthier

  • 1Service d'hépatologie pédiatrique, Hôpital Bicêtre, AP-HP, Pôle adolescent-mère-enfant, Le Kremlin-Bicêtre Cedex, France.

Presse Medicale (Paris, France : 1983)
|July 7, 2009
PubMed
Summary
This summary is machine-generated.

Pediatric liver transplantation (LT) in children, often using partial grafts, faces complications like sepsis and EBV-related disease. Despite challenges, long-term survival is high, with most children achieving a good quality of life post-transplant.

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Last Updated: Jun 21, 2026

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Area of Science:

  • Pediatric Hepatology
  • Transplantation Surgery
  • Immunology

Context:

  • Liver transplantation (LT) in children under 16 represents 6-8% of annual LT procedures in France.
  • Indications are primarily neonatal cholestatic diseases, with biliary atresia being the most common.
  • Pediatric LT often involves partial liver grafts due to the recipients' young age (median 2 years).

Purpose:

  • To review the indications, surgical considerations, and outcomes of pediatric liver transplantation.
  • To identify specific complications and survival rates in pediatric LT recipients.
  • To highlight long-term graft survival and quality of life in this population.

Summary:

  • Pediatric LT commonly uses partial grafts, increasing risks of vascular and biliary complications compared to whole-liver transplants.
  • Sepsis is a primary early cause of mortality.
  • Specific complications in young children include EBV-related post-transplantation lymphoproliferative disease, food allergies (tacrolimus-related), and acquired renal cystic disease (cyclosporine-related).

Impact:

  • Despite early complications, 10-year survival rates for pediatric LT exceed 70-80%.
  • Health-related quality of life post-transplantation is generally close to normal.
  • Late graft failure, primarily due to chronic rejection from immunosuppressant non-adherence, affects about 10% of children.