Related Experiment Video

Updated: Jun 21, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

EUS in pediatric patients

Tan Attila1, Douglas G Adler, Kristen Hilden

  • 1Division of Gastroenterology and Hepatology, Oregon Health & Science University, Portland, Oregon 97239-3098, USA.

Gastrointestinal Endoscopy
|July 7, 2009
PubMed

Insights

Endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) are safe and effective in diagnosing pediatric gastrointestinal, pancreatobiliary, and mediastinal diseases. This study highlights their significant clinical utility in young patients.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Endoscopy
  • Diagnostic Imaging

Background:

  • Limited data exists on the application and efficacy of endoscopic ultrasound (EUS) in pediatric populations.
  • Pediatric gastrointestinal, pancreatobiliary, and mediastinal diseases often present diagnostic challenges.

Purpose of the Study:

  • To evaluate the indications, feasibility, safety, and clinical utility of EUS in managing pediatric GI, pancreatobiliary, and mediastinal conditions.
  • To assess the diagnostic yield of EUS-guided fine-needle aspiration (EUS-FNA) in children.

Main Methods:

  • Retrospective analysis of 40 EUS procedures performed in 38 children (mean age 13.5 years) across two tertiary referral centers.
  • Review of indications, procedural success, diagnostic outcomes, and complications.

Main Results:

  • EUS indications included pancreatobiliary (pancreatitis, masses), gastric (lesions), and mediastinal (masses/nodes) evaluations.
  • EUS-guided fine-needle aspiration (EUS-FNA) was performed in 12 cases (30%), achieving a 75% diagnostic rate.
  • The procedures were successful in all patients with no reported complications.

Conclusions:

  • Endoscopic ultrasound (EUS) and EUS-FNA are safe and feasible diagnostic tools in pediatric patients.
  • EUS has a significant impact on the clinical management of diverse pediatric diseases.
  • Further research can expand the role of EUS in pediatric care.
Abstract

More Related Videos

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...