Neopterin levels and left ventricular dysfunction in patients with chronic stable angina pectoris

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Published on: October 1, 2019

Rodrigo Estévez-Loureiro1, Alejandro Recio-Mayoral, Juan A Sieira-Rodríguez-Moret

  • 1Cardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St George's, University of London, London, UK.

Atherosclerosis
|July 7, 2009
PubMed

Insights

In patients with chronic stable angina, elevated neopterin levels, a marker of inflammation, are linked to reduced left ventricular ejection fraction (LVEF). High neopterin independently predicts left ventricular dysfunction, aiding in risk stratification.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Left ventricular ejection fraction (LVEF) is crucial for survival in chronic stable angina (CSA) patients.
  • Inflammation is implicated in atherosclerosis and negatively impacts patient outcomes.
  • The relationship between inflammation and left ventricular (LV) function in CSA is not well understood.

Purpose of the Study:

  • To investigate the correlation between inflammatory markers (C-reactive protein and neopterin) and LV function in CSA patients.
  • To determine if neopterin or CRP predict LV dysfunction in this population.

Main Methods:

  • 181 patients with CSA undergoing coronary angiography were studied.
  • Serum concentrations of high-sensitivity C-reactive protein (hs-CRP) and neopterin were measured before angiography.

Main Results:

  • Neopterin, but not CRP, showed a significant inverse correlation with LVEF.
  • Neopterin was independently associated with LVEF after adjusting for confounders.
  • High neopterin levels independently predicted LV dysfunction (LVEF <45%) with an odds ratio of 8.52.
  • Neopterin demonstrated good predictive value for LV dysfunction (AUC=0.736).

Conclusions:

  • Increased serum neopterin concentrations correlate with lower LVEF in CSA patients.
  • High neopterin levels are an independent predictor of LV dysfunction, regardless of coronary artery disease severity.
  • Neopterin may serve as a valuable biomarker for risk stratification in CSA.
Abstract

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