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Updated: Jun 21, 2026
14:14
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
Anatomo-pathological analysis after CoreValve Revalving system implantation
Stéphane Noble1, Anita Asgar, Raymond Cartier
1Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Summary
Pathological analysis of percutaneous aortic valve replacement (PAVR) with the CoreValve Revalving System shows encouraging results. Early neointimal coverage of the native valve site and no excessive pannus formation were observed.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
- Pathology
Background:
- Percutaneous aortic valve replacement (PAVR) has advanced significantly, yet long-term behavior of implanted devices requires investigation.
- The CoreValve Revalving System is a widely used device for PAVR.
Observation:
- Autopsy analysis was performed on four patients who died at varying intervals (3-350 days) post-CoreValve implantation.
- Gross examination revealed neointimal tissue covering frame struts, with bare areas in high-velocity flow regions.
- Histopathology showed early fibrin deposition and inflammation, progressing to neointimal coverage and reduced inflammation over time.
Findings:
- Neointimal tissue formation was observed on the CoreValve frame, particularly where it contacted the aortic wall.
- Inflammatory responses were present early post-implantation but regressed as neointimal coverage increased.
- No significant pannus formation was noted on the valve leaflets in this early cohort.
Implications:
- Anatomical assessment suggests favorable tissue response to the CoreValve device in the short-to-medium term.
- Findings support the safety of PAVR regarding tissue ingrowth and pannus formation.
- Further long-term echocardiographic follow-up is needed to correlate anatomical findings with clinical outcomes.
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