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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Quality of life in postmenopausal women, users and non-users of hormone therapy]
Marcelo Antonio Domingos Martins1, Eliana Aguiar Petri Nahas, Jorge Nahas-Neto
1Programa de Pós-graduação em Ginecologia, Obstetrícia e Mastologia da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio de Mesquita Filho - Botucatu (SP), Brasil.
Purpose:
to evaluate the quality of life of post-menopause women, users and non-users of hormonal therapy (HT), in a Healthcare Unit in Franca, São Paulo, Brazil.
Methods:
a clinical transversal study, carried out with 250 post-menopausal women, with ages from 45 to 70 years old, attended to in Healthcare Units, from September 2007 to August 2008. Participants were divided into two groups: HT users (n=70) and non-users (n=180). Women making continuous HT use for at least six months were considered as users. Sociodemographic and clinical characteristics have been evaluated. Blatt-Kupperman's menopausal index has been applied to assess climacteric symptoms, and the Women's Health Questionnaire (WHQ), to assess their quality of life. Fisher's exact test or chi2 and Mann-Whitney and Kruskal-Wallis's tests have been used for the statistical analysis.
Results:
no significant difference has been found in the comparison of groups, concerning age, menarche, menopause, parity and body mass index. It has been seen that 67.2% of the women were married, 83.2% had attended primary school and 53.2% were housewives, with no difference between the groups. HT users reported lower frequency of climacteric symptoms (BKMI) with moderate and marked intensity, as compared to non-users (p<0.001). Even though HT users presented lower average score in cognitive deficit (p<0.001), vasomotor symptoms (p=0.04), sleeping problems (p<0.001), attractiveness (p=0.02) from the WHQ, there has been no difference in the total score, as compared to non-users.
Conclusions:
post-menopausal women, HT users and non-users, admitted at Healthcare Units, have not presented differences in global quality of life.
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