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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jun 21, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Bmi-1, stem cells and cancer.

Lili Jiang¹, Jun Li, Libing Song

¹State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.

Acta Biochimica Et Biophysica Sinica

|July 7, 2009

Summary

Bmi-1, a key gene in cell cycle regulation, influences stem cell self-renewal and differentiation. This review summarizes its role as a transcriptional regulator, clarifying its molecular mechanisms in stem cells.

Area of Science:

Molecular Biology
Stem Cell Biology
Genetics

Background:

Bmi-1 is a polycomb gene family member crucial for cell cycle regulation, immortalization, and senescence.
Emerging research highlights Bmi-1's involvement in regulating stem cell self-renewal and differentiation.
The precise molecular mechanisms governing Bmi-1's function in stem cells are not fully understood.

Purpose of the Study:

To review and summarize the known functions of Bmi-1.
To elucidate Bmi-1's role as a transcriptional regulator of gene expression.
To focus on the specific implications of Bmi-1 in the context of stem cells.

Main Methods:

Literature review of recent studies on Bmi-1.
Analysis of Bmi-1's function as a transcriptional regulator.

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Synthesis of findings related to stem cell biology.

Main Results:

Bmi-1 acts as a transcriptional regulator, influencing gene expression patterns.
The review consolidates evidence linking Bmi-1 to the control of stem cell self-renewal.
Bmi-1's role in stem cell differentiation processes is highlighted.

Conclusions:

Bmi-1 is a significant transcriptional regulator with critical roles in stem cell biology.
Understanding Bmi-1's mechanisms is essential for advancing stem cell research.
Further investigation into Bmi-1's molecular functions will clarify its impact on stem cell fate.